{"id":13036,"date":"2023-12-05T09:52:02","date_gmt":"2023-12-05T08:52:02","guid":{"rendered":"https:\/\/evolute-institute.com\/?p=13036"},"modified":"2024-12-14T16:37:49","modified_gmt":"2024-12-14T15:37:49","slug":"microdosagem-vs-macrodosagem-de-substancias-psicadelicas-para-o-crescimento-pessoal","status":"publish","type":"post","link":"https:\/\/evolute-institute.com\/pt\/psychedelics\/microdosing-vs-macrodosing-psychedelics-for-personal-growth\/","title":{"rendered":"Devo fazer uma microdose ou uma macrodose de subst\u00e2ncias psicad\u00e9licas? | Caminhos para o Crescimento Pessoal com Psilocibina e LSD"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"13036\" class=\"elementor elementor-13036\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6b1eceeb elementor-hidden-desktop e-flex e-con-boxed e-con e-parent\" data-id=\"6b1eceeb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5850ab2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5850ab2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9403c3 elementor-author-box--layout-image-above elementor-author-box--align-center elementor-author-box--avatar-yes elementor-author-box--name-yes elementor-author-box--biography-yes elementor-author-box--link-no elementor-widget elementor-widget-author-box\" data-id=\"d9403c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/about-dmitrij-achelrod\/\" target=\"_blank\" class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/secure.gravatar.com\/avatar\/6e54c36f755ae3fd41e547a25bba882c7d4beac706bca752869c47e7236b271d?s=300&#038;r=g\" alt=\"Picture of Dmitrij Achelrod PhD\" loading=\"lazy\">\n\t\t\t\t<\/a>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/about-dmitrij-achelrod\/\" target=\"_blank\">\n\t\t\t\t\t\t<h4 class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tDmitrij Achelrod PhD\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t<\/a>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\tDr. Dmitrij Achelrod (PhD) is passionate about advancing human and planetary well-being. With an extensive background in healthcare and data science, Dmitrij has pioneered AI-powered solutions at high-growth tech startups, served on advisory boards in digital therapeutics companies, and co-founded Evolute Institute to cultivate wisdom in leadership circles.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6cdc345 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6cdc345\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-206aadf8 elementor-widget elementor-widget-text-editor\" data-id=\"206aadf8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Contributing Authors<br \/><a href=\"https:\/\/www.linkedin.com\/in\/nino-galvez-leferink\/\" target=\"_blank\" rel=\"noopener\">Nino Galvez Leferink<\/a> | Feature image by <a href=\"https:\/\/unsplash.com\/@mikael_k?utm_content=creditCopyText&amp;utm_medium=referral&amp;utm_source=unsplash\" target=\"_blank\" rel=\"noopener\">Mikael Kristenson<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2d99583 elementor-hidden-mobile e-flex e-con-boxed e-con e-parent\" data-id=\"2d99583\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0b67e78 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0b67e78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b75a700 elementor-author-box--layout-image-left elementor-author-box--align-left elementor-author-box--image-valign-middle elementor-author-box--avatar-yes elementor-author-box--name-yes elementor-author-box--biography-yes elementor-author-box--link-no elementor-widget elementor-widget-author-box\" data-id=\"2b75a700\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/about-dmitrij-achelrod\/\" target=\"_blank\" class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/secure.gravatar.com\/avatar\/6e54c36f755ae3fd41e547a25bba882c7d4beac706bca752869c47e7236b271d?s=300&#038;r=g\" alt=\"Picture of Dmitrij Achelrod PhD\" loading=\"lazy\">\n\t\t\t\t<\/a>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/about-dmitrij-achelrod\/\" target=\"_blank\">\n\t\t\t\t\t\t<h4 class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tDmitrij Achelrod PhD\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t<\/a>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\tDr. Dmitrij Achelrod (PhD) is passionate about advancing human and planetary well-being. With an extensive background in healthcare and data science, Dmitrij has pioneered AI-powered solutions at high-growth tech startups, served on advisory boards in digital therapeutics companies, and co-founded Evolute Institute to cultivate wisdom in leadership circles.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6232c3c1 elementor-widget elementor-widget-text-editor\" data-id=\"6232c3c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Contributing Authors<br \/><a href=\"https:\/\/www.linkedin.com\/in\/nino-galvez-leferink\/\" target=\"_blank\" rel=\"noopener\">Nino Galvez Leferink<\/a> | Feature image by <a href=\"https:\/\/unsplash.com\/@mikael_k?utm_content=creditCopyText&amp;utm_medium=referral&amp;utm_source=unsplash\" target=\"_blank\" rel=\"noopener\">Mikael Kristenson<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b734e0e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b734e0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34c3f899 e-flex e-con-boxed e-con e-parent\" data-id=\"34c3f899\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3db25338 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"3db25338\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The field of personal development has witnessed the advent of psychedelic substances as tools for transformation. Grounded in scientific research, psychedelics have demonstrated substantial effects on the brain and have been linked with benefits for mental well-being and spiritual enrichment, particularly in the context of high-dose experiences to improve mental health.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, more and more people find it impractical to regularly indulge in high-dose psilocybin journeys or sometimes are worried about the intensity of such high-dose journeys. Instead, they try to include regular dosing of psychedelics, such as psilocybin or LSD, in much smaller quantities in their daily lives. This practice is called psychedelic microdosing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Microdosing and macrodosing are two such modalities that offer distinctive paths to self-development and self-discovery, each utilizing a varying dose and context to our path of personal growth. This article delves into the potential of both microdosing and macrodosing for personal growth, comparing its benefits and downsides. It took us weeks to write this article and to review the available evidence on microdosing and macrodosing so that you don&#8217;t have to. We hope it enlightens your path forward.&nbsp;<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">1. What is microdosing?<\/span><\/h2>\n<p><img decoding=\"async\" class=\"alignright wp-image-13062\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/microdosing.webp\" alt=\"microdosing psychedelics, low intensity\" width=\"300\" height=\"543\" srcset=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/microdosing.webp 509w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/microdosing-166x300.webp 166w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/microdosing-7x12.webp 7w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Microdosing involves taking \u201cmicro\u201d or very small, sub-perceptual quantities of substances such as LSD or psilocybin. The doses are typically a small fraction of a full-dose that would be used in macrodosing Usually, we are talking about 1\/5 down to 1\/20 of a macro dose. Proponents of this method claim it&nbsp; enhances mood, productivity, mindfulness, creativity, and cognition without significant perceptual alterations or psychedelic experiences. As the article \u201cHow Silicon Valley rediscovered LSD\u201d<\/span><span style=\"font-weight: 400;\">[1]<\/span><span style=\"font-weight: 400;\"> shows, microdosing is heralded by creative minds and corporate leaders for its propensity to cultivate out-of-the-box thinking and heightened productivity, thereby transcending the bounds of personal development to touch upon professional excellence.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The recent surge in popularity of microdosing has its roots in James Fadiman&#8217;s 2011 book, &#8220;The Psychedelic Explorers Guide.&#8221;<\/span><span style=\"font-weight: 400;\">[2]<\/span><span style=\"font-weight: 400;\"> This publication brought the concept of microdosing into the mainstream, sparking a wave of personal accounts, media coverage, and scientific studies on the topic. One of the most popular accounts of the positive impacts of microdosing is Ayelet Waldman\u2019s book \u201cA Really Good Day\u201d.<\/span><span style=\"font-weight: 400;\">[3]<\/span><span style=\"font-weight: 400;\"> Ayelet Waldman, a successful public federal defender, struggled with deep depression beneath her outward success. Inspired by James Fadiman&#8217;s work on microdosing, she decided to try it herself and experienced a profound transformation. For the first time, she felt that something helps against her depression. She overcame her mood swings and gained newfound confidence. This journey not only altered her mental health but also fundamentally changed her perspective on life.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">2. Summing up the scientific evidence<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While all those individual reports about the positive effects of microdosing sound alluring,&nbsp; the question is if those anecdotal claims of microdosing really can be substantiated?<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><br>What is clear is that the scientific evaluation of microdosing benefits is still in its nascent stages. Unfortunately, the answer isn&#8217;t clear-cut if microdosing is really effective. While certain research suggests tangible benefits from microdosing, other studies offer less compelling evidence, showing minimal or no advantages. For instance, a recent observational study involving almost 1000 individuals microdosing psilocybin and almost 200 non-microdosing participants over a month revealed modest enhancements in mood and mental health, consistent across various demographics and mental health statuses.<\/span><span style=\"font-weight: 400;\">[4]<\/span><span style=\"font-weight: 400;\"> Such findings align with numerous personal accounts praising microdosing&#8217;s positive impacts.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, not all research on microdosing yields such positive results. A notable study employed a randomized controlled trial, the gold standard for eliminating placebo effects, involving 34 participants.<\/span><span style=\"font-weight: 400;\">[5]<\/span><span style=\"font-weight: 400;\"> They were divided, with half receiving psilocybin and the other half a placebo. Despite some subjective improvements in happiness and creativity, and even alterations in EEG-recorded brain activity, the study found no concrete evidence of enhanced creativity, well-being, or cognitive function with low-dose psilocybin. This research supports the theory that the benefits perceived from microdosing at these lower levels might largely stem from expectation<\/span><span style=\"font-weight: 400;\">[6]<\/span><span style=\"font-weight: 400;\">, suggesting that higher doses might be necessary for therapeutic effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most comprehensive review study on microdosing, so far, was conducted by Polito et al. in 2022. After reviewing 44 studies, some of which were published back in the 1960\u2019s, the authors came to the following conclusion: There is good evidence that psychedelic microdosing can lower pain perception<\/span><span style=\"font-weight: 400;\">[7]<\/span><span style=\"font-weight: 400;\">, and influence subjective awareness. Improvements in mental health, substance use disorders, and psychological functioning could not be confidently substantiated.<\/span><span style=\"font-weight: 400;\">[8]<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The summary of their findings is shown in the following table, separated by study type.<\/span><\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 1rem 0; font-size: 0.9em; font-family: , Tahoma, Geneva, Verdana, sans-serif; box-shadow: 0 0 20px rgba(0, 0, 0, 0.15);\">\n<caption style=\"margin-top: 0.5em; margin-bottom: 0.75em; font-size: 1.5rem; font-weight: bold;\"><strong>High-level overview of the effects of microdosing (adapted from Polito et al. 2022)<\/strong><\/caption>\n<thead style=\"background-color: #f2ba61; color: #ffffff; text-align: left;\">\n<tr>\n<th style=\"padding: 12px 10px;\">Observed Effects from Both Self-Reports and Laboratory Studies<\/th>\n<th style=\"padding: 12px 10px;\">Reported Effects in Self-Reports but Insufficiently Explored in Labs<\/th>\n<th style=\"padding: 12px 10px;\">Reported Effects in Self-Reports, but not Confirmed in Lab Settings<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Altered perception of time<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Enhanced mental health<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Elevation in mood<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Increased pain threshold<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Decrease in drug use<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Strengthened social bonds<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Shifts in conscious state<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Greater uptake<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Improved mental processes<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Descreased mind wandering<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Increased emotional awareness<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Shifts in personality traits<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Improved energy<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Increased psychological insight<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Connection with nature<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">General wellbeing<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">Inceased creative thinking<\/td>\n<td style=\"border-bottom: 1px solid #dddddd; padding: 12px 15px;\">&nbsp;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>3. How can I benefit from microdosing?<\/h2>\n<h3>Mood and Mental Health<\/h3>\n<p><span style=\"font-weight: 400;\">Microdosing has been commonly associated with improved mood in various qualitative, retrospective, prospective, and laboratory studies<\/span><span style=\"font-weight: 400;\">[9], [10]<\/span><span style=\"font-weight: 400;\">.&nbsp; It has also been linked with lower depression scores, although some studies, especially well-controlled laboratory ones, did not find significant changes in depression, negative affect, or positive affect scores on dosing days.<\/span><span style=\"font-weight: 400;\">[11],<\/span><span style=\"font-weight: 400;\"> The impact on anxiety and stress showed mixed results, with some studies reporting decreases and others increases or mixed outcomes.<\/span><span style=\"font-weight: 400;\">[11], [12]<\/span><span style=\"font-weight: 400;\"> Substance misuse improvements were reported, particularly in qualitative studies, with microdosing linked to reductions in smoking and substance use. However, these effects have not been widely investigated in laboratory settings.<\/span><span style=\"font-weight: 400;\">[6]<\/span><span style=\"font-weight: 400;\"> Moreover, some studies associated microdosing with improved general mental health and reduced OCD severity. <\/span><span style=\"font-weight: 400;\">[7], [9]\u2013[26]<\/span><\/p>\n<h3>Wellbeing and Attitudes<\/h3>\n<p><span style=\"font-weight: 400;\">Increases in wellbeing, self-fulfilment, self-efficacy, and resilience were reported in three qualitative and one retrospective survey study. However, no laboratory-based studies have investigated these aspects yet. <\/span><span style=\"font-weight: 400;\">[6], [8], [15], [27]<\/span><\/p>\n<h3>Creativity and Cognition<\/h3>\n<p><span style=\"font-weight: 400;\">Several studies indicated that microdosing may be associated with increases in creativity<\/span><span style=\"font-weight: 400;\">[28]<\/span><span style=\"font-weight: 400;\">, with reports of enhanced convergent and divergent thinking. However, findings were not consistent across all studies. Some studies showed changes in neurocognitive behavioural tasks, such as impacts on time perception and selective attention, but again, results varied, with some studies reporting no significant effects.<\/span><span style=\"font-weight: 400;\">[13]\u2013[15], [16], [18], [21], [22], [29]\u2013[31]<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<h3>Personality<\/h3>\n<p><span style=\"font-weight: 400;\">Reports on personality changes due to microdosing were less consistent. Some studies reported increases in traits like openness and extraversion, while others did not find significant changes in the classic big five personality traits. Notably, most experiments focused on acute rather than long-term changes, limiting insights into lasting personality alterations. Studies consistently reported increases in interpersonal feelings, attitudes, and behaviors, indicating improved relationships and interpersonal connections. <\/span><span style=\"font-weight: 400;\">[6], [9], [12], [18], [21], [22], [27], [32]\u2013[34]<\/span><\/p>\n<h3>Changes in Conscious State<\/h3>\n<p><span style=\"font-weight: 400;\">Despite claims that microdosing is sub-perceptual, evidence suggests that it leads to changes in subjective awareness. A qualitative analysis indicated changes in psychophysiological state, characterized by heightened presence and perceptual clarity, believed to be essential for the beneficial effects of microdosing. <\/span><span style=\"font-weight: 400;\">[18], [20], [22], [22], [30], [35]\u2013[42]<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Summing up, initial studies point to potential advantages; however, the scientific community pleads for more high-quality research to substantiate these findings.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">4. Is microdosing safe?<br>&#8211; <\/span><span style=\"font-weight: 400;\">T<\/span><span style=\"font-weight: 400;\">he hidden dangers of microdosing<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">We do not have enough evidence about risks related to long-term use. But one of the biggest concerns is that prolonged use of psilocybin in microdosing might cause valvular heart disease because of the chronic activation of serotonin 2B receptors.<\/span><span style=\"font-weight: 400;\">[43]<\/span> <span style=\"font-weight: 400;\"><br><\/span><span style=\"font-weight: 400;\"><br><\/span><span style=\"font-weight: 400;\">Valvular heart disease (VHD) involves the impairment of heart valves responsible for managing blood circulation in and out of the heart, leading to symptoms like breathlessness, general weakness, and even the risk of sudden heart-related death. Medications that strongly interact with the serotonin 2B receptor (5HT2B) have been implicated as a potential cause for VHD. For example, up to one quarter of chronic users of the common prescription medications methylergonovine, methysergide, ergotamine, pergolide, cabergoline, and fenfluramine develop VHD. This is most likely because these drugs exhibit a marked 5HT2B receptor binding affinity.<\/span><span style=\"font-weight: 400;\">[44]<\/span><span style=\"font-weight: 400;\"> Because LSD and psilocybin are known for their binding to the 5HT2B receptor, this might be concerning when these substances are used in small, consistent doses over long periods.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a study involving 29 MDMA users who took an average of 3.6 MDMA pills weekly for over half a decade, almost one third were found to have mild to moderate VHD. This was a notable contrast to a control group, where no instances of VHD were reported.<\/span><span style=\"font-weight: 400;\">[45]<\/span><span style=\"font-weight: 400;\"> This study signals a concerning trend, as LSD and psilocybin, commonly used in microdosing, bind more strongly to the 5HT2B receptor than MDMA. It is very clear that more research on the safety of microdosing is needed before it can be considered safe.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another downside of microdosing might be the tolerance the body builds to these substances, making them ineffective if not followed in a structured regimen where the intake is paused. Tolerance seems to be gained more quickly with LSD than with psilocybin.<\/span><span style=\"font-weight: 400;\">[46]<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<h2>5. Macrodosing Psychedelics in a Retreat Context<\/h2>\n<p><img decoding=\"async\" class=\"wp-image-13063 alignleft\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/Untitled-design-2.webp\" alt=\"macrodosing psychedelics, high intensity\" width=\"300\" height=\"558\" srcset=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/Untitled-design-2.webp 496w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/Untitled-design-2-161x300.webp 161w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/Untitled-design-2-6x12.webp 6w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Macrodosing, on the other hand, involves consuming a large or &#8216;macro&#8217; dose of a psychedelic substance. An approach best undertaken within a safe, legal and well-guided retreat setting. To learn about how to pick a well-facilitated psychedelic retreat that suits you, see <a href=\"https:\/\/evolute-institute.com\/psychedelics\/how-to-pick-a-psychedelic-retreat\/\">this article<\/a>.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A well-guided macrodose experience induces a powerful experience characterized by significant alterations in perception, mood, and cognitive processes. Often this experience is described, like pioneering researcher Prof. Roland Griffiths did, as \u201cineffable\u201d, meaning that one can not put words to the experience. Study participants described their macrodosing journey as one of the most profound experiences in their lives, comparing them to the birth of their children or the death of a close relative or loved one.<\/span><span style=\"font-weight: 400;\">[47]<\/span><span style=\"font-weight: 400;\"> If you are still curious, you can find our attempt to describe it <a href=\"https:\/\/evolute-institute.com\/psychedelics\/101\/a-peek-inside-the-psychedelic-experience\/\">here<\/a>. A macro dose, in an ideal environment, can create a deeply meaningful, insightful, introspective experience that, when integrated effectively, can forge persistent beneficial impacts on an individual\u2019s self-understanding, emotional wellbeing, outlook on life and spiritual growth.<\/span><span style=\"font-weight: 400;\">[47]<\/span><span style=\"font-weight: 400;\"> The benefits of a macro dose psychedelic experience do not depend on continually taking the substance. On the contrary, many people report that one macrodose psychedelic experience has been so significant that it has shown them enough for them to integrate and take action on for years.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In stark contrast to microdosing, there is a substantial body of scientific evidence showing that macrodosing (particularly with psilocybin) is, under the right conditions (!), a safe practice&nbsp;[48]\u2013[51] and can have positive effects in ill and healthy populations on a wide range of factors, ranging from psychological dimensions like mood, over spiritual well-being to physiological changes like increased neuroplasticity.&nbsp;<\/span><span style=\"font-weight: 400;\">[52]\u2013[57]<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The intensity of macrodosing can be overwhelming, potentially leading to temporary psychological discomfort. Therefore, professional guidance within a supportive setting is highly recommended to ensure safety and maximize the benefits of the experience. Participants should always be screened for certain preexisting psychiatric disorders, for their psychological stability and for other factors (e.g. medical history, medication intake\u2026) by qualified medical professionals before engaging in a macrodose journey. Otherwise, a macrodose journey can do more harm than good and destabilize people.&nbsp;&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Substances commonly used for macrodosing in retreat contexts are the \u201cclassic psychedelics\u201d which include psilocybin (magic mushrooms), LSD, DMT (ayahuasca), and mescaline (peyote and San Pedro cacti), selected on their psychoactive profile and the desired duration and depth of the experience.<\/span><\/p>\n<h3>Something in between the micro dose and the macro dose<\/h3>\n<p><img decoding=\"async\" class=\"size-full wp-image-13058 aligncenter\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a.webp\" alt=\"increasing intensity with a knob as a psychedelic dose increases\" width=\"1075\" height=\"614\" srcset=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a.webp 1075w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a-300x171.webp 300w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a-1024x585.webp 1024w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a-768x439.webp 768w, https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/11\/DALL\u00b7E-2023-11-09-13.46.57-Craft-an-image-that-visually-communicates-the-concept-of-increasing-intensity-in-perception-with-larger-doses-of-psychedelics-using-a-metaphor-that-a-18x10.webp 18w\" sizes=\"(max-width: 1075px) 100vw, 1075px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">In our article titled \u201c<a href=\"https:\/\/evolute-institute.com\/psychedelics\/101\/a-peek-inside-the-psychedelic-experience\/\" target=\"_blank\" rel=\"noopener\">A peek into the psychedelic mind<\/a>\u201d, we describe how the relationship between the dose one takes and what one experiences, can be compared to a dial. As you turn the dial up, by taking a higher dose, the experience becomes more intense and the person influenced becomes more vulnerable. So yes, there is a lot in between a micro dose and a macro dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">We believe that the appeal of a microdose is that there is no risk for a so-called \u201c<a href=\"https:\/\/evolute-institute.com\/psychedelics\/101\/the-psychedelic-bad-trip-paradox\/\" target=\"_blank\" rel=\"noopener\">bad trip<\/a>\u201d, because there are no perceptual effects or drastic changes in consciousness. It can be used more casually, in day-to-day life, and it is more affordable than a well-facilitated retreat. However, microdosing will never be able to provide one the depth of experience and potential for transformation that one can have when undergoing a macrodose psychedelic experience. It is normal to fear such an experience more, because we don\u2019t want a bad experience and we don\u2019t know who we will be after the macrodose journey ends.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before stepping into the unknown of a macro psychedelic experience, it is a normal and healthy sign to experience excitement and slight nervousness. Through proper preparation, guidance and being in the right setting, one can learn to trust and to surrender and let go into the experience. That is the key to prevent a \u201cbad trip\u201d from happening (besides ensuring medical eligibility, of course). If you are curious to learn more about bad trips, what causes them and how to prevent them, <a href=\"https:\/\/evolute-institute.com\/psychedelics\/101\/the-psychedelic-bad-trip-paradox\/\" target=\"_blank\" rel=\"noopener\">have a look at this article<\/a>.<\/span><\/p>\n<h3>What dosage do we use in our psychedelic retreat programs?<\/h3>\n<p><span style=\"font-weight: 400;\">In our psychedelic retreat programs <a href=\"https:\/\/evolute-institute.com\/evolead\/\">EvoLEAD<\/a> and <a href=\"https:\/\/evolute-institute.com\/evocore-psychedelic-retreat-program\/\">EvoCORE<\/a>, the on-site facilitation team consisting of medical doctors, clinical psychologists, and ceremonial facilitators carefully decides on a personally-tailored dose of psychedelic truffles for each participant. We do not work with microdoses, since we craft a safe container for a deeper experience. The dosage each participant receives is partly determined by the results of the medical-psychological screening, but also by keeping in mind what the retreat participant wants to discover and what she is ready for. Lastly, it is also based on how the participant responds to the holotropic-style breathwork which we usually do on Day 1 of the retreats (holotropic breathwork helps to get to know altered states of consciousness already and serves as a preparation for the psilocybin-containing truffle experience on the next day).<\/span><\/p>\n<h2>7. Conclusion: Microdosing vs. Macrodosing<\/h2>\n<p><span style=\"font-weight: 400;\">As we have seen, microdosing and macrodosing serve different and potentially complementary pathways to personal growth and development. However, the depth to which they have impact on our lives is very different.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Microdosing is often the regimen of choice for those seeking to subtly enhance daily life, such as having gentle creative boosts. The scientific evidence on the benefits of microdosing is not strong and warrants further investigations. There might be safety issues when microdosing psychedelics over prolonged periods of time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the other hand, macrodosing, particularly in the context of a well-facilitated psychedelic retreat, is sought after for its capacity to facilitate profound introspection, transformational psychological development and\/or integration (\u201chealing\u201c), without the need for continuous use. The scientific evidence on the safety and effectiveness of macrodosed psychedelics (particularly psilocybin) is strong.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As a final note: no matter in which way you engage with a psychedelic substance, but especially as the dose goes up, the importance of the right preparation, framing, guidance, setting, understanding and support cannot be emphasized enough to ensure a beneficial and safe experience. Have a look at our article <a href=\"https:\/\/evolute-institute.com\/psychedelics\/how-to-pick-a-psychedelic-retreat\/\">HOW TO PICK A PSYCHEDELIC RETREAT THAT RESONATES WITH YOUR PERSONAL VALUES AND BELIEFS<\/a> to get a better feeling for what to look out for when considering a psychedelic retreat provider.<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p><p><span style=\"font-size: 19.2px;\">Please bear in mind that we do not provide medical advise and you should always seek assistance from a medical professional before making any decision about consuming psychedelics.<\/span><br><\/p>\n<div class=\"elementor-element elementor-element-3a51ff2d elementor-widget elementor-widget-text-editor\" data-id=\"3a51ff2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">&nbsp;<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad3ec9a elementor-widget elementor-widget-text-editor\" data-id=\"ad3ec9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Bibliography on Microdosing<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">[1]<\/span> <span style=\"font-weight: 400;\">H. Kuchler, \u201cHow Silicon Valley rediscovered LSD,\u201d Financial Times, Aug. 10, 2017. Accessed: Nov. 27, 2023. [Online]. Available: https:\/\/www.ft.com\/content\/0a5a4404-7c8e-11e7-ab01-a13271d1ee9c<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[2]<\/span> <span style=\"font-weight: 400;\">\u201cThe Psychedelic Explorer\u2019s Guide | Dr. James Fadiman\u2019s manual offers helpful and well-informed guidance for those who seek \u2018the divine within\u2019 through sacred plants and psychedelic substances.\u201d Accessed: Nov. 27, 2023. [Online]. Available: https:\/\/www.psychedelicexplorersguide.com\/<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[3]<\/span> <span style=\"font-weight: 400;\">\u201cA Really Good Day by Ayelet Waldman: 9781101973721 | PenguinRandomHouse.com: Books,\u201d PenguinRandomhouse.com. Accessed: Nov. 27, 2023. [Online]. Available: https:\/\/www.penguinrandomhouse.com\/books\/545767\/a-really-good-day-by-ayelet-waldman\/<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[4]<\/span> <span style=\"font-weight: 400;\">J. M. Rootman et al., \u201cPsilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls,\u201d Sci. Rep., vol. 12, no. 1, Art. no. 1, Jun. 2022, doi: 10.1038\/s41598-022-14512-3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[5]<\/span> <span style=\"font-weight: 400;\">F. Cavanna et al., \u201cMicrodosing with psilocybin mushrooms: a double-blind placebo-controlled study,\u201d Transl. Psychiatry, vol. 12, no. 1, Art. no. 1, Aug. 2022, doi: 10.1038\/s41398-022-02039-0.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[6]<\/span> <span style=\"font-weight: 400;\">L. S. Kaertner et al., \u201cPositive expectations predict improved mental-health outcomes linked to psychedelic microdosing,\u201d Sci. Rep., vol. 11, no. 1, Art. no. 1, Jan. 2021, doi: 10.1038\/s41598-021-81446-7.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[7]<\/span> <span style=\"font-weight: 400;\">J. G. Ramaekers et al., \u201cA low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers,\u201d J. Psychopharmacol. Oxf. Engl., vol. 35, no. 4, pp. 398\u2013405, Apr. 2021, doi: 10.1177\/0269881120940937.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[8]<\/span> <span style=\"font-weight: 400;\">V. Polito and P. Liknaitzky, \u201cThe emerging science of microdosing: A systematic review of research on low dose psychedelics (1955\u20132021) and recommendations for the field,\u201d Neurosci. Biobehav. Rev., vol. 139, p. 104706, Aug. 2022, doi: 10.1016\/j.neubiorev.2022.104706.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[9]<\/span> <span style=\"font-weight: 400;\">\u201cJohnstad, P. G. (2018). Powerful substances in tiny amounts: An interview study of psychedelic microdosing. Nordic Studies on Alcohol and Drugs, 35(1), 39-<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[10]<\/span> <span style=\"font-weight: 400;\">\u201cAnderson, T., Petranker, R., Christopher, A., Rosenbaum, D., Weissman, C., Dinh-Williams, L.-A., Hui, K., and Hapke, E. (2019a). Psychedelic microdosing benefits and challenges: an empirical codebook. Harm Reduction Journal, 16(1), 43.\u201d.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[11]<\/span> <span style=\"font-weight: 400;\">L. P. Cameron, C. J. Benson, L. E. Dunlap, and D. E. Olson, \u201cEffects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression,\u201d ACS Chem. Neurosci., vol. 9, no. 7, pp. 1582\u20131590, Jul. 2018, doi: 10.1021\/acschemneuro.8b00134.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[12]<\/span> <span style=\"font-weight: 400;\">\u201cPsilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial &#8211; Roland R Griffiths, Matthew W Johnson, Michael A Carducci, Annie Umbricht, William A Richards, Brian D Richards, Mary P Cosimano, Margaret A Klinedinst, 2016.\u201d Accessed: Nov. 27, 2023. [Online]. Available: https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/0269881116675513<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[13]<\/span> <span style=\"font-weight: 400;\">J. Fadiman and S. Korb, \u201cMight Microdosing Psychedelics Be Safe and Beneficial? An Initial Exploration,\u201d J. Psychoactive Drugs, vol. 51, no. 2, pp. 118\u2013122, 2019, doi: 10.1080\/02791072.2019.1593561.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[14]<\/span> <span style=\"font-weight: 400;\">T. Lea, N. Amada, H. Jungaberle, H. Schecke, and M. Klein, \u201cMicrodosing psychedelics: Motivations, subjective effects and harm reduction,\u201d Int. J. Drug Policy, vol. 75, p. 102600, Jan. 2020, doi: 10.1016\/j.drugpo.2019.11.008.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[15]<\/span> <span style=\"font-weight: 400;\">M. Webb, H. Copes, and P. S. Hendricks, \u201cNarrative identity, rationality, and microdosing classic psychedelics,\u201d Int. J. Drug Policy, vol. 70, pp. 33\u201339, Aug. 2019, doi: 10.1016\/j.drugpo.2019.04.013.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[16]<\/span> <span style=\"font-weight: 400;\">T. Anderson et al., \u201cMicrodosing psychedelics: personality, mental health, and creativity differences in microdosers,\u201d Psychopharmacology (Berl.), vol. 236, no. 2, pp. 731\u2013740, Feb. 2019, doi: 10.1007\/s00213-018-5106-2.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[17]<\/span> <span style=\"font-weight: 400;\">N. R. P. W. Hutten, N. L. Mason, P. C. Dolder, and K. P. C. Kuypers, \u201cMotives and Side-Effects of Microdosing With Psychedelics Among Users,\u201d Int. J. Neuropsychopharmacol., vol. 22, no. 7, pp. 426\u2013434, Jul. 2019, doi: 10.1093\/ijnp\/pyz029.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[18]<\/span> <span style=\"font-weight: 400;\">B. Szigeti et al., \u201cSelf-blinding citizen science to explore psychedelic microdosing,\u201d eLife, vol. 10, p. e62878, Mar. 2021, doi: 10.7554\/eLife.62878.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[19]<\/span> <span style=\"font-weight: 400;\">N. R. P. W. Hutten et al., \u201cMood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study,\u201d Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol., vol. 41, pp. 81\u201391, Dec. 2020, doi: 10.1016\/j.euroneuro.2020.10.002.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[20]<\/span> <span style=\"font-weight: 400;\">H. Isbell, \u201cComparison of the reactions induced by psilocybin and LSD-25 in man,\u201d Psychopharmacologia, vol. 1, pp. 29\u201338, 1959, doi: 10.1007\/BF00408109.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[21]<\/span> <span style=\"font-weight: 400;\">V. Polito and R. J. Stevenson, \u201cA systematic study of microdosing psychedelics,\u201d PLOS ONE, vol. 14, no. 2, p. e0211023, Feb. 2019, doi: 10.1371\/journal.pone.0211023.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[22]<\/span> <span style=\"font-weight: 400;\">A. K. Bershad, S. T. Schepers, M. P. Bremmer, R. Lee, and H. de Wit, \u201cAcute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers,\u201d Biol. Psychiatry, vol. 86, no. 10, pp. 792\u2013800, Nov. 2019, doi: 10.1016\/j.biopsych.2019.05.019.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[23]<\/span> <span style=\"font-weight: 400;\">A. K. Bershad et al., \u201cPreliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity,\u201d Biol. Psychiatry Cogn. Neurosci. Neuroimaging, vol. 5, no. 4, pp. 461\u2013467, Apr. 2020, doi: 10.1016\/j.bpsc.2019.12.007.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[24]<\/span> <span style=\"font-weight: 400;\">A. Kjellgren, A. Eriksson, and T. Norlander, \u201cExperiences of Encounters with Ayahuasca\u2014\u2018the Vine of the Soul,\u2019\u201d J. Psychoactive Drugs, vol. 41, no. 4, pp. 309\u2013315, Dec. 2009, doi: 10.1080\/02791072.2009.10399767.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[25]<\/span> <span style=\"font-weight: 400;\">P. Gasser, K. Kirchner, and T. Passie, \u201cLSD-assisted psychotherapy for anxiety associated with a life-threatening disease: a qualitative study of acute and sustained subjective effects,\u201d J. Psychopharmacol. Oxf. Engl., vol. 29, no. 1, pp. 57\u201368, Jan. 2015, doi: 10.1177\/0269881114555249.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[26]<\/span> <span style=\"font-weight: 400;\">F. A. Moreno, C. B. Wiegand, E. K. Taitano, and P. L. Delgado, \u201cSafety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder,\u201d J. Clin. Psychiatry, vol. 67, no. 11, pp. 1735\u20131740, Nov. 2006, doi: 10.4088\/jcp.v67n1110.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[27]<\/span> <span style=\"font-weight: 400;\">T. Anderson et al., \u201cPsychedelic microdosing benefits and challenges: an empirical codebook,\u201d Harm. Reduct. J., vol. 16, no. 1, p. 43, Jul. 2019, doi: 10.1186\/s12954-019-0308-4.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[28]<\/span> <span style=\"font-weight: 400;\">J. N. Bonnieux, B. VanderZwaag, Z. Premji, A. Garcia-Romeu, and M. A. Garcia-Barrera, \u201cPsilocybin\u2019s effects on cognition and creativity: A scoping review,\u201d J. Psychopharmacol. (Oxf.), vol. 37, no. 7, pp. 635\u2013648, Jul. 2023, doi: 10.1177\/02698811231179801.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[29]<\/span> <span style=\"font-weight: 400;\">L. Prochazkova, D. P. Lippelt, L. S. Colzato, M. Kuchar, Z. Sjoerds, and B. 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Nardou et al., \u201cPsychedelics reopen the social reward learning critical period,\u201d Nature, vol. 618, no. 7966, Art. no. 7966, Jun. 2023, doi: 10.1038\/s41586-023-06204-3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a35ee80 e-con-full e-flex e-con e-parent\" data-id=\"5a35ee80\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5727cd00 e-flex e-con-boxed e-con e-child\" data-id=\"5727cd00\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cc32647 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-image\" data-id=\"2cc32647\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/elementor\/thumbs\/Dimi_square_small-quwrl0uy8h45j3yjqp1hxd4h7qll64z8ll1tf84c0g.jpg\" title=\"Dimi_square_small\" alt=\"Dimi_square_small\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c7067d elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1c7067d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Dmitrij Achelrod<\/strong>,<\/p><p>Co-Founder Evolute Institute<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6b01100e e-con-full e-flex e-con e-child\" data-id=\"6b01100e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6c62e20 elementor-widget elementor-widget-heading\" data-id=\"6c62e20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Feeling inspired?<br>LET'S talk<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4745c808 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4745c808\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We invite you to schedule a call with us. Together, we can delve into any questions you might have. We can explore whether one of our retreat programs is right for you at this time.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37185cff elementor-widget elementor-widget-html\" data-id=\"37185cff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<!-- Calendly link widget begin -->\r\n<link href=\"https:\/\/assets.calendly.com\/assets\/external\/widget.css\" rel=\"stylesheet\">\r\n<script src=\"https:\/\/assets.calendly.com\/assets\/external\/widget.js\" type=\"text\/javascript\" async><\/script>\r\n<div align=\"center\">\r\n    <a class=\"sch_appt_cal\" href=\"\" onclick=\"Calendly.initPopupWidget({url: 'https:\/\/calendly.com\/evolute_institute_da\/30-min-exploration-evolute'});return false;\">START YOUR JOURNEY<\/a>\r\n    <!-- Calendly link widget end -->\r\n<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-138f0297 elementor-widget elementor-widget-text-editor\" data-id=\"138f0297\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e200368 e-flex e-con-boxed e-con e-parent\" data-id=\"2e200368\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Contributing AuthorsNino Galvez Leferink | Feature image by Mikael Kristenson Contributing AuthorsNino Galvez Leferink | Feature image by Mikael Kristenson The field of personal development has witnessed the advent of psychedelic substances as tools for transformation. Grounded in scientific research, psychedelics have demonstrated substantial effects on the brain and have been linked with benefits for [&hellip;]<\/p>\n","protected":false},"author":1491,"featured_media":13067,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[56,52,58,57,51],"tags":[],"class_list":["post-13036","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all","category-personal-development-leadership","category-insights-and-practical-advice","category-research","category-psychedelics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Should I Microdose or Macrodose Psychedelics? | Pathways to Personal Growth with Psilocybin &amp; LSD | Evolute Institute<\/title>\n<meta name=\"description\" content=\"We delve into the science based potential of micro and macro dosing psychedelics for personal growth, comparing benefits and downsides.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/evolute-institute.com\/pt\/psicadelicos\/microdosagem-vs-macrodosagem-de-substancias-psicadelicas-para-o-crescimento-pessoal\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Should I Microdose or Macrodose Psychedelics? 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