{"id":9615,"date":"2023-08-09T21:46:55","date_gmt":"2023-08-09T19:46:55","guid":{"rendered":"https:\/\/evolute-institute.com\/?p=9615"},"modified":"2025-07-31T13:01:56","modified_gmt":"2025-07-31T11:01:56","slug":"o-teu-cerebro-sobre-psicadelicos-uma-introducao-a-neurociencia-psicadelica","status":"publish","type":"post","link":"https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/","title":{"rendered":"O teu c\u00e9rebro com subst\u00e2ncias psicad\u00e9licas: Introdu\u00e7\u00e3o \u00e0 Neuroci\u00eancia da Psilocibina &amp; Co."},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9615\" class=\"elementor elementor-9615\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6a81ba8b elementor-hidden-desktop e-flex e-con-boxed e-con e-parent\" data-id=\"6a81ba8b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bd34bb5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"bd34bb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3073c976 elementor-author-box--layout-image-above elementor-author-box--align-center elementor-author-box--avatar-yes elementor-author-box--name-yes elementor-author-box--biography-yes elementor-author-box--link-no elementor-widget elementor-widget-author-box\" data-id=\"3073c976\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/pt\/sobre-dmitrij-achelrod\/\" target=\"_blank\" class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/secure.gravatar.com\/avatar\/6e54c36f755ae3fd41e547a25bba882c7d4beac706bca752869c47e7236b271d?s=300&#038;r=g\" alt=\"Fotografia de Dmitrij Achelrod PhD\" loading=\"lazy\">\n\t\t\t\t<\/a>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/pt\/sobre-dmitrij-achelrod\/\" target=\"_blank\">\n\t\t\t\t\t\t<h4 class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tDmitrij Achelrod Doutoramento\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t<\/a>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\tO Dr. Dmitrij Achelrod (PhD) \u00e9 apaixonado pelo avan\u00e7o do bem-estar humano e planet\u00e1rio. Com uma extensa experi\u00eancia em cuidados de sa\u00fade e ci\u00eancia de dados, Dmitrij foi pioneiro em solu\u00e7\u00f5es alimentadas por IA em startups de tecnologia de alto crescimento, atuou em conselhos consultivos em empresas de terap\u00eautica digital e co-fundou a Evolute Institute para cultivar a sabedoria em c\u00edrculos de lideran\u00e7a.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1257460c elementor-widget elementor-widget-text-editor\" data-id=\"1257460c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Autor colaborador<br \/><a href=\"https:\/\/www.linkedin.com\/in\/nino-galvez-leferink\">Nino Galvez<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d50568e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d50568e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e89c66d elementor-hidden-mobile elementor-hidden-tablet e-flex e-con-boxed e-con e-parent\" data-id=\"2e89c66d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-873c0e7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"873c0e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e47a3a7 elementor-author-box--layout-image-left elementor-author-box--align-left elementor-author-box--image-valign-middle elementor-author-box--avatar-yes elementor-author-box--name-yes elementor-author-box--biography-yes elementor-author-box--link-no elementor-widget elementor-widget-author-box\" data-id=\"6e47a3a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/pt\/sobre-dmitrij-achelrod\/\" target=\"_blank\" class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/secure.gravatar.com\/avatar\/6e54c36f755ae3fd41e547a25bba882c7d4beac706bca752869c47e7236b271d?s=300&#038;r=g\" alt=\"Fotografia de Dmitrij Achelrod PhD\" loading=\"lazy\">\n\t\t\t\t<\/a>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/evolute-institute.com\/pt\/sobre-dmitrij-achelrod\/\" target=\"_blank\">\n\t\t\t\t\t\t<h4 class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tDmitrij Achelrod Doutoramento\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t<\/a>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\tO Dr. Dmitrij Achelrod (PhD) \u00e9 apaixonado pelo avan\u00e7o do bem-estar humano e planet\u00e1rio. Com uma extensa experi\u00eancia em cuidados de sa\u00fade e ci\u00eancia de dados, Dmitrij foi pioneiro em solu\u00e7\u00f5es alimentadas por IA em startups de tecnologia de alto crescimento, atuou em conselhos consultivos em empresas de terap\u00eautica digital e co-fundou a Evolute Institute para cultivar a sabedoria em c\u00edrculos de lideran\u00e7a.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-549d56cb elementor-widget elementor-widget-text-editor\" data-id=\"549d56cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Autor colaborador<br \/><a href=\"https:\/\/www.linkedin.com\/in\/nino-galvez-leferink\">Nino Galvez<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20721651 e-flex e-con-boxed e-con e-parent\" data-id=\"20721651\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a310e1a elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a310e1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a5eafdb elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"3a5eafdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>O que se passa no c\u00e9rebro sob a influ\u00eancia de subst\u00e2ncias psicad\u00e9licas, incluindo o LSD, a psilocibina e o DMT?<\/h2>\n<p><b><\/b>Os psicad\u00e9licos t\u00eam um impacto profundo na consci\u00eancia humana. Neste artigo, vamos aprofundar os fundamentos neurobiol\u00f3gicos destas subst\u00e2ncias que alteram a mente atrav\u00e9s de uma perspetiva cient\u00edfica. Iremos esclarecer a investiga\u00e7\u00e3o de ponta e os conhecimentos fundamentais sobre a forma como estas drogas interagem com o c\u00e9rebro. A nossa explora\u00e7\u00e3o centrar-se-\u00e1 principalmente nos psicad\u00e9licos mais frequentemente utilizados e extensivamente investigados, conhecidos como \"psicad\u00e9licos serotonin\u00e9rgicos\": Dietilamida do \u00e1cido lis\u00e9rgico (LSD), psilocibina e N, N-dimetiltriptamina (DMT). Entra no mundo dos neurotransmissores e do \"c\u00e9rebro an\u00e1rquico\".<\/p>\n<p><!-- \/wp:paragraph --><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a80d78c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a80d78c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>A liga\u00e7\u00e3o dos neurotransmissores<\/h2>\n<p><img decoding=\"async\" style=\"color: var( --e-global-color-text ); text-align: var(--text-align); font-size: 17px; letter-spacing: 0px;\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/2023\/08\/serotonin-receptor-297x300.webp\" alt=\"A estrutura de um recetor de serotonina 5-H2A ativado por psicad\u00e9licos.\" width=\"297\" height=\"300\" data-wp-editing=\"1\" \/><\/p>\n<p><i>A estrutura de um recetor de serotonina 5-H2A ativado por psicad\u00e9licos.<\/i><span id='easy-footnote-1-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-1-9615' title='&lt;a href=&quot;https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6136989\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Canal, C. E. (2018). Psicod&eacute;licos Serotonin&eacute;rgicos: Abordagens experimentais para avaliar os mecanismos de a&ccedil;&atilde;o. Manual de Farmacologia Experimental, 252, 227. https:\/\/doi.org\/10.1007\/164_2018_107&lt;\/a&gt;'><sup>1<\/sup><\/a><\/span>\u00a0<\/p>\n<p><span style=\"color: var( --e-global-color-text ); letter-spacing: 0px; text-align: var(--text-align);\">A serotonina encontra-se no nosso c\u00e9rebro, uma vez que \u00e9 um neurotransmissor. Modula o humor, a cogni\u00e7\u00e3o, a aprendizagem, a mem\u00f3ria e v\u00e1rios processos fisiol\u00f3gicos como a vasoconstri\u00e7\u00e3o (o estreitamento dos vasos sangu\u00edneos, atrav\u00e9s da contra\u00e7\u00e3o de pequenos m\u00fasculos nas suas paredes).\u00a0<\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Um grupo de investigadores concorda que a ativa\u00e7\u00e3o do recetor 5-HT2A \u00e9 necess\u00e1ria para a maioria dos efeitos psicoactivos das subst\u00e2ncias psicad\u00e9licas serotonin\u00e9rgicas.<span style=\"text-indent: -18pt; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-2-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-2-9615' title='&lt;\/span&gt;&lt;span lang=&quot;EN-US&quot; style=&quot;text-indent: -18pt; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/26841800\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Nichols DE. Psychedelics. Pharmacol Rev. 2016 Apr;68(2):264-355. doi: 10.1124\/pr.115.011478. Errata em: Pharmacol Rev. 2016 Apr;68(2):356. PMID: 26841800; PMCID: PMC4813425&lt;\/a&gt;'><sup>2<\/sup><\/a><\/span>\u00a0<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">As subst\u00e2ncias psicad\u00e9licas activam esses receptores atrav\u00e9s da m\u00edmica<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">rege as ac\u00e7\u00f5es da serotonina para produzir os efeitos psicoactivos.<\/span><span lang=\"EN-US\" style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px; text-indent: -18pt;\"><span id='easy-footnote-3-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-3-9615' title='&lt;a href=&quot;https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867420310667&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Kim K, Che T, Panova O, et al. Estrutura de um Recetor de Serotonina 5-HT2A Acoplado a Gq Ativado por Alucinog&eacute;nio. C&eacute;lula 2020; 182: 1574-1588.e19&lt;\/a&gt;'><sup>3<\/sup><\/a><\/span>\u00a0<\/span><span style=\"color: var( --e-global-color-text ); letter-spacing: 0px; text-align: var(--text-align);\">\u00c9 por isso que os psicad\u00e9licos s\u00e3o referidos como agonistas (parciais) desse recetor espec\u00edfico no c\u00e9rebro. Como podes ver abaixo, quimicamente, alguns destes compostos s\u00e3o muito semelhantes \u00e0 serotonina.<\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e92c473 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e92c473\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure><\/figure>\n<p><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/mDrhYIx5oUkWiW6vWBPTx8fPrFHa3cdyB0iFbPPYaN0kXL5TErLcfK7NtFQwbG_ePBVlpMa7X7jjyQvRG8FoaIbbmP3gxX-oPt6yzTsXrOn9OsSBVV30Mju9N3GJgNsSDwx0viFULchABd5askGhKfg\" alt=\"\" width=\"600\" height=\"200\"> Fonte da imagem<span id='easy-footnote-4-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-4-9615' title=' &lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/26841800\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Nichols DE. Psychedelics. Pharmacol Rev. 2016 Apr;68(2):264-355. doi: 10.1124\/pr.115.011478. Errata em: Pharmacol Rev. 2016 Apr;68(2):356. PMID: 26841800; PMCID: PMC4813425&lt;\/a&gt;'><sup>4<\/sup><\/a><\/span><\/p>\n<h2>Como \u00e9 que sabemos o que acontece no c\u00e9rebro?<\/h2>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">A nossa compreens\u00e3o do modo como as subst\u00e2ncias psicad\u00e9licas funcionam e provocam altera\u00e7\u00f5es no nosso comportamento j\u00e1 percorreu um longo caminho, gra\u00e7as aos grandes saltos nas t\u00e9cnicas de imagiologia cerebral como a eletroencefalografia (EEG), a magnetoencefalografia (MEG) e a resson\u00e2ncia magn\u00e9tica funcional (fMRI). Estes m\u00e9todos forneceram informa\u00e7\u00f5es valiosas sobre as interac\u00e7\u00f5es intrincadas entre a atividade cerebral e o comportamento em resposta a subst\u00e2ncias psicad\u00e9licas. Segue-se uma vis\u00e3o geral da evolu\u00e7\u00e3o da utiliza\u00e7\u00e3o destas t\u00e9cnicas ao longo do tempo. Podes deduzir do gr\u00e1fico que, desde 2010, a utiliza\u00e7\u00e3o da fMRI para a psilocibina e o LSD tem sido particularmente proeminente.<\/span><\/p>\n<p><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">&nbsp;<\/span><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/Yb-pzcoY94aRLrQN0DFEJHOTjP3ryclV8q54T_YVhZBwYgy2NsWpshh0z-nU3t5HSFfULivGfcJDlKMsC1eRg-304ZkMLfCiehroisCuJez12q0825rju0p0aTksVrcmY2YFhFYp6K0DMRgR0GqOuWA\" alt=\"Evolu\u00e7\u00e3o das t\u00e9cnicas de neuroimagem\" width=\"584\" height=\"344\">&nbsp;<\/p>\n<p><i>Fonte: Psicad\u00e9licos e neuroimagem fNIRS: explora novas oportunidades.<\/i><span lang=\"EN-US\" style=\"text-indent: -18pt; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-kerning: auto; font-optical-sizing: auto; font-feature-settings: normal; font-variation-settings: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';\">&nbsp;<\/span><\/span><span lang=\"EN-US\" style=\"text-indent: -18pt; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-5-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-5-9615' title='&lt;a href=&quot;https:\/\/www.spiedigitallibrary.org\/journals\/neurophotonics\/volume-10\/issue-01\/013506\/Psychedelics-and-fNIRS-neuroimaging-exploring-new-opportunities\/10.1117\/1.NPh.10.1.013506.full?SSO=1#r83&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Felix Scholkmann, Franz X. Vollenweider,&lt;br&gt;&quot;Psicad&eacute;licos e neuroimagem fNIRS: explorando novas oportunidades,&quot;&lt;br&gt;Neurophoton. 10(1) 013506 (2 de dezembro de 2022)&lt;\/a&gt;'><sup>5<\/sup><\/a><\/span><\/span><\/p>\n<p style=\"text-indent: -18.0pt; mso-list: l0 level1 lfo1;\">\n<\/p><p><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">O Prof. Karl Friston \u00e9 um pioneiro no campo da fMRI e o neurocientista mais frequentemente citado na hist\u00f3ria. Friston e os seus colegas propuseram uma teoria que elucida a mec\u00e2nica do funcionamento dos psicad\u00e9licos no c\u00e9rebro. A sua teoria, conhecida como \"REBUS e o C\u00e9rebro An\u00e1rquico: Toward a Unified Model of the Brain Action of Psychedelics\", representa uma incurs\u00e3o intrigante neste campo de estudo. Mais tarde, abordaremos o modelo REBUS.<\/span><span lang=\"EN-US\" style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px; text-indent: -18pt;\"><span id='easy-footnote-6-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-6-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/31221820\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Carhart-Harris RL, Friston KJ. REBUS e o C&eacute;rebro An&aacute;rquico: Rumo a um modelo unificado da a&ccedil;&atilde;o cerebral dos psicad&eacute;licos. Pharmacol Rev. 2019 Jul;71(3):316-344. doi: 10.1124\/pr.118.017160. PMID: 31221820; PMCID: PMC6588209&lt;\/a&gt;'><sup>6<\/sup><\/a><\/span><\/span><\/p>\n<p style=\"text-indent: -18.0pt; mso-list: l0 level1 lfo1;\">\n<\/p><p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h2>Interliga\u00e7\u00e3o em regi\u00f5es do c\u00e9rebro<\/h2>\n<div>&nbsp;<\/div>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image --><\/p>\n<figure><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/lh5.googleusercontent.com\/-Gxy4P4f1VWfkXqDC9yBNBTH_PDnJJIcKf1iMzwiFtAgFuI2zCSuhxEaV1aC5w7HwrXy6h7XyH61ze_Ku0VAeQHJUg1_as9zcXAfgooyPKhY-j4F45uuqGPqfn2xQu-ba_l0m2IC9hA0iSLdx_P6Mws\" alt=\"\"><\/figure>\n<figure><em style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">Fonte da imagem<\/em><span lang=\"EN-US\" style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-7-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-7-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/25401177\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Petri G, Expert P, Turkheimer F, Carhart-Harris R, Nutt D, Hellyer PJ, Vaccarino F. Homological scaffolds of brain functional networks. J R Soc Interface. 2014 Dec 6;11(101):20140873. doi: 10.1098\/rsif.2014.0873. PMID: 25401177; PMCID: PMC4223908.&lt;\/a&gt;&lt;\/span&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>7<\/sup><\/a><\/span><\/span><\/figure>\n<p>Acima tens uma representa\u00e7\u00e3o fascinante do c\u00e9rebro humano sob a influ\u00eancia de subst\u00e2ncias psicad\u00e9licas. Esta visualiza\u00e7\u00e3o simplificada da interconectividade do c\u00e9rebro sob placebo e sob psilocibina apoia a ideia de que a psilocibina perturba a organiza\u00e7\u00e3o normal do c\u00e9rebro com o aparecimento de liga\u00e7\u00f5es funcionais fortes, topologicamente de longo alcance, que n\u00e3o est\u00e3o presentes num estado normal.<span lang=\"EN-US\" style=\"text-indent: -18pt; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-8-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-8-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/25401177\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Petri G, Expert P, Turkheimer F, Carhart-Harris R, Nutt D, Hellyer PJ, Vaccarino F. Homological scaffolds of brain functional networks. J R Soc Interface. 2014 Dec 6;11(101):20140873. doi: 10.1098\/rsif.2014.0873. PMID: 25401177; PMCID: PMC4223908&lt;\/a&gt;'><sup>8<\/sup><\/a><\/span><\/span><\/p>\n<p><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">Assim, os psicad\u00e9licos facilitam um aumento significativo da conetividade entre diferentes partes do c\u00e9rebro, permitindo uma explora\u00e7\u00e3o profunda de diferentes estados de esp\u00edrito.<\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Este aumento da conetividade de certas regi\u00f5es cerebrais pode indicar que o c\u00e9rebro est\u00e1 num estado de superalimenta\u00e7\u00e3o. No entanto, alguns estudos sugerem que, sob a influ\u00eancia de subst\u00e2ncias psicad\u00e9licas, a atividade do c\u00e9rebro, medida em termos de fluxo sangu\u00edneo, \u00e9 significativamente reduzida. Esta \u00e9 uma descoberta intrigante que criou uma ant\u00edtese ao modelo REBUS para compreender a experi\u00eancia psicad\u00e9lica.<span style=\"background-color: transparent; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-9-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-9-9615' title='&lt;a href=&quot;https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3277566\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A. 2012 Fev 7;109(6):2138-43. doi: 10.1073\/pnas.1119598109. Epub 2012 Jan 23. PMID: 22308440; PMCID: PMC3277566&lt;\/a&gt;'><sup>9<\/sup><\/a><\/span><\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h2>Default Mode Network (DMN) - o \"Executivo\"<\/h2>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Falar de diminui\u00e7\u00e3o da atividade no c\u00e9rebro leva-nos \u00e0 Rede de Modo Padr\u00e3o (DMN). \u00c9 uma rede de regi\u00f5es cerebrais interligadas que est\u00e1 mais ativa quando a tua mente est\u00e1 concentrada e preocupada contigo. Quando est\u00e1s a sonhar acordado, a refletir sobre ti pr\u00f3prio e a pensar no teu passado ou futuro, est\u00e1s a aceder \u00e0 DMN. A DMN \u00e9 uma rede importante no c\u00e9rebro, uma vez que as suas regi\u00f5es associadas s\u00e3o as que consomem mais fluxo sangu\u00edneo<span style=\"background-color: transparent; color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-10-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-10-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/19607928\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Zou Q, Wu CW, Stein EA, Zang Y, Yang Y. Caracter&iacute;sticas est&aacute;ticas e din&acirc;micas do fluxo sangu&iacute;neo cerebral durante o estado de repouso. Neuroimage. 2009 Nov 15;48(3):515-24. doi: 10.1016\/j.neuroimage.2009.07.006. Epub 2009 Jul 14. PMID: 19607928; PMCID: PMC2739419&lt;\/a&gt;'><sup>10<\/sup><\/a><\/span> <\/span>e energia<span id='easy-footnote-11-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-11-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/17719799\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Raichle ME, Snyder AZ. Um modo predefinido de funcionamento do c&eacute;rebro: uma breve hist&oacute;ria de uma ideia em evolu&ccedil;&atilde;o. Neuroimage. 2007 Oct 1;37(4):1083-90; discuss&atilde;o 1097-9. doi: 10.1016\/j.neuroimage.2007.02.041. Epub 2007 Mar 6. PMID: 17719799&lt;\/a&gt;'><sup>11<\/sup><\/a><\/span> no c\u00e9rebro.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Esta rede \u00e9 vital para o nosso sentido do eu. Algumas das tuas cren\u00e7as mais fundamentais sobre ti pr\u00f3prio est\u00e3o instanciadas na DMN. Considera-a como o arquiteto por detr\u00e1s da nossa narrativa e identidade pessoais, moldando a linha entre o \"eu\" e o \"outro\" e mantendo o nosso pensamento autorreferencial. Al\u00e9m disso, o DMN desempenha um papel na forma como avaliamos e percebemos a nossa import\u00e2ncia e valor no mundo. Por isso, \u00e9 tamb\u00e9m o nosso l\u00edder de claque pessoal. Est\u00e1 envolvido no processamento emocional autorreferencial, que inclui as nossas reflex\u00f5es sobre as realiza\u00e7\u00f5es individuais, o nosso estatuto em compara\u00e7\u00e3o com os outros e o nosso sentido geral de autoestima. Algumas pessoas chamam-lhe mesmo o nosso \"CEO\" ou o \"Executivo\" do nosso c\u00e9rebro.<\/p>\n<p>A DMN \u00e9 um sistema que tem suscitado grande interesse na investiga\u00e7\u00e3o sobre a depress\u00e3o grave. A investiga\u00e7\u00e3o mostra que as pessoas que sofrem de depress\u00e3o t\u00eam uma DMN mais ativa. O DMN est\u00e1 associado \u00e0 gera\u00e7\u00e3o de pensamentos auto-referenciais, \u00e0 rumina\u00e7\u00e3o negativa e aos sintomas depressivos.<span id='easy-footnote-12-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-12-9615' title='&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/21531382\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Farb NA, Anderson AK, Bloch RT, Segal ZV. Mood-linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression. Biol Psychiatry. 2011 Aug 15;70(4):366-72. doi: 10.1016\/j.biopsych.2011.03.009. Epub 2011 Apr 30. PMID: 21531382; PMCID: PMC3145008&lt;\/a&gt;'><sup>12<\/sup><\/a><\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>No que diz respeito aos psicad\u00e9licos, os estudos mostraram que subst\u00e2ncias como o LSD, a psilocibina e o DMT podem perturbar o funcionamento t\u00edpico da DMN. Diminui a sua atividade. Como explor\u00e1mos no artigo \"<a href=\"https:\/\/evolute-institute.com\/pt\/espreita-por-dentro-da-experiencia-psicadelica\/\" target=\"_blank\" rel=\"noopener\">Uma espreitadela na mente psicad\u00e9lica<\/a>\", um bot\u00e3o que desce quando est\u00e1s sob a influ\u00eancia de um psicad\u00e9lico. Esse bot\u00e3o pode ser representado pelo DMN. \u00c0 medida que se vai baixando, leva a experi\u00eancias de dissolu\u00e7\u00e3o do ego, onde a fronteira entre o \"eu\" e o \"outro\" come\u00e7a a desaparecer. Como vimos no artigo \"<a href=\"https:\/\/evolute-institute.com\/pt\/o-paradoxo-psicadelico-da-ma-viagem\/\" target=\"_blank\" rel=\"noopener\">artigo sobre viagens m\u00e1s<\/a>\", estar pronto para se libertar durante a experi\u00eancia, talvez das nossas imagens do eu instanciadas no DMN, \u00e9 fundamental para evitar uma experi\u00eancia significativamente desconfort\u00e1vel.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>A redu\u00e7\u00e3o da auto-import\u00e2ncia e do foco em si mesmo pode explicar porque \u00e9 que muitos utilizadores relatam sentimentos de unidade e interconex\u00e3o com o mundo \u00e0 sua volta durante as experi\u00eancias psicad\u00e9licas. Express\u00f5es como \"levantar o v\u00e9u\" e \"abrir as portas da perce\u00e7\u00e3o\" para uma experi\u00eancia maior fazem mais sentido neste contexto.<\/p>\n<p>Curiosamente, estudos descobriram que na medita\u00e7\u00e3o, especialmente em meditadores experientes, a atividade da DMN tamb\u00e9m \u00e9 significativamente reduzida<span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-13-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-13-9615' title='&lt;\/span&gt;&lt;a style=&quot;text-align: var(--text-align); letter-spacing: 0px; background-color: #ffffff;&quot; href=&quot;https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4529365\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Garrison KA, Zeffiro TA, Scheinost D, Constable RT, Brewer JA. A medita&ccedil;&atilde;o leva &agrave; redu&ccedil;&atilde;o da atividade da rede de modo padr&atilde;o para al&eacute;m de uma tarefa ativa. Cogn Affect Behav Neurosci. 2015 Sep;15(3):712-20. doi: 10.3758\/s13415-015-0358-3. PMID: 25904238; PMCID: PMC4529365&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>13<\/sup><\/a><\/span> <\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">- um paralelo com a experi\u00eancia psicad\u00e9lica que est\u00e1 a ser explorada pelos investigadores.<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px; font-family: 'Times New Roman'; font-size: medium;\"><span id='easy-footnote-14-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-14-9615' title='&lt;\/span&gt;&lt;a style=&quot;text-align: var(--text-align); letter-spacing: 0px; background-color: #ffffff;&quot; href=&quot;https:\/\/www.nature.com\/articles\/tp201740&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Wise, T., Marwood, L., Perkins, A. M., Joules, R., Lythgoe, D. J., Luh, W., Williams, S. C., Young, A. H., Cleare, A. J., &amp;amp; Arnone, D. (2017). Instabilidade da conetividade da rede de modo padr&atilde;o na depress&atilde;o maior: Um estudo de confirma&ccedil;&atilde;o de duas amostras. &lt;em&gt;Psiquiatria translacional&lt;\/em&gt;, &lt;em&gt;7&lt;\/em&gt;(4), e1105. https:\/\/doi.org\/10.1038\/tp.2017.40&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px; font-family: &#039;Times New Roman&#039;; font-size: medium;&quot;&gt;'><sup>14<\/sup><\/a><\/span><\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h2>O brilho psicad\u00e9lico posterior: Altera\u00e7\u00f5es cerebrais a curto e a longo prazo<\/h2>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>O fen\u00f3meno do \"afterglow\" que se segue ao uso de subst\u00e2ncias psicad\u00e9licas, tipicamente caracterizado por uma sensa\u00e7\u00e3o duradoura de clareza, melhoria emocional e vivacidade perceptiva, encontrou agora uma explica\u00e7\u00e3o fascinante com ra\u00edzes na neuroci\u00eancia.&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>De acordo com um estudo realizado por investigadores da Johns Hopkins Medicine, as subst\u00e2ncias psicad\u00e9licas podem potencialmente reabrir \"per\u00edodos cr\u00edticos\" no c\u00e9rebro<span id='easy-footnote-15-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-15-9615' title='&lt;a href=&quot;https:\/\/www.nature.com\/articles\/s41586-023-06204-3&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Nardou, R., Sawyer, E., Song, Y. J., Wilkinson, M., De Deus, J. L., Wright, N., Lama, C., Faltin, S., Goff, L. A., L., G., &amp;amp; D&ouml;len, G. (2023). Os psicad&eacute;licos reabrem o per&iacute;odo cr&iacute;tico de aprendizagem da recompensa social. &lt;em&gt;Natureza&lt;\/em&gt;, &lt;em&gt;618&lt;\/em&gt;(7966), 790-798. https:\/\/doi.org\/10.1038\/s41586-023-06204-3&lt;\/a&gt;'><sup>15<\/sup><\/a><\/span>O per\u00edodo cr\u00edtico \u00e9 uma fase em que o c\u00e9rebro demonstra uma maior sensibilidade aos sinais ambientais, influenciando assim o seu desenvolvimento. Presume-se que o per\u00edodo cr\u00edtico \u00e9 mais elevado na inf\u00e2ncia e na adolesc\u00eancia e diminui progressivamente \u00e0 medida que atingimos a idade adulta. \u00c9 not\u00e1vel que, dependendo do psicad\u00e9lico espec\u00edfico consumido, estes per\u00edodos cr\u00edticos podem ser reabertos e mantidos abertos entre dois dias a quatro semanas com apenas uma dose<span id='easy-footnote-16-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-16-9615' title='&lt;a href=&quot;https:\/\/www.nature.com\/articles\/s41586-023-06204-3&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Nardou, R., Sawyer, E., Song, Y. J., Wilkinson, M., De Deus, J. L., Wright, N., Lama, C., Faltin, S., Goff, L. A., L., G., &amp;amp; D&ouml;len, G. (2023). Os psicad&eacute;licos reabrem o per&iacute;odo cr&iacute;tico de aprendizagem da recompensa social. &lt;em&gt;Natureza&lt;\/em&gt;, &lt;em&gt;618&lt;\/em&gt;(7966), 790-798. https:\/\/doi.org\/10.1038\/s41586-023-06204-3&lt;\/a&gt;'><sup>16<\/sup><\/a><\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">.<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">&nbsp;<\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image --><\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/q_TJwgTs8IHxRgz40e-6NjZ-vh_O2PV_Lni9IS6dxnjoMedm0My0qtQpLqSZDgzGulaKSHvns29twb2W23OhYw4GSxVRhBtsLC9vNiUgZ4ifv-RZ0AFgOV4QY_6d2ew_ZhAd2CLHuQtcUVv1GE27tJo\" alt=\"\"><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><em>A dura\u00e7\u00e3o da reabertura do per\u00edodo cr\u00edtico est\u00e1 correlacionada com a dura\u00e7\u00e3o dos efeitos subjectivos de cada medicamento. <span id='easy-footnote-17-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-17-9615' title='&lt;a href=&quot;https:\/\/www.nature.com\/articles\/s41586-023-06204-3&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Nardou, R., Sawyer, E., Song, Y. J., Wilkinson, M., De Deus, J. L., Wright, N., Lama, C., Faltin, S., Goff, L. A., L., G., &amp;amp; D&ouml;len, G. (2023). Os psicad&eacute;licos reabrem o per&iacute;odo cr&iacute;tico da aprendizagem da recompensa social. Nature, 618(7966), 790-798. https:\/\/doi.org\/10.1038\/s41586-023-06204-3&lt;\/a&gt;'><sup>17<\/sup><\/a><\/span><\/em><\/p>\n<p><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">Investiga\u00e7\u00f5es anteriores demonstraram que os per\u00edodos cr\u00edticos desempenham um papel crucial em diversas fun\u00e7\u00f5es, como a aquisi\u00e7\u00e3o da linguagem nos seres humanos<span id='easy-footnote-18-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-18-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/29729947\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Hartshorne JK, Tenenbaum JB, Pinker S. Um per&iacute;odo cr&iacute;tico para a aquisi&ccedil;&atilde;o de uma segunda l&iacute;ngua: Evidence from 2\/3 million English speakers. Cognition. 2018 Aug;177:263-277. doi: 10.1016\/j.cognition.2018.04.007. Epub 2018 May 2. PMID: 29729947; PMCID: PMC6559801.&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>18<\/sup><\/a><\/span>, p\u00e1ssaros a aprender a cantar<span id='easy-footnote-19-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-19-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/doi.org\/10.1007%2FBF01905355&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Lorenz, K. Der Kumpan in der Umwelt des Vogels.&amp;nbsp;&lt;em&gt;J. Ornitol&lt;\/em&gt;&amp;nbsp;&lt;strong&gt;83&lt;\/strong&gt;, 137-213 (1935).&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>19<\/sup><\/a><\/span>reaprende as capacidades motoras depois de um AVC<span id='easy-footnote-20-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-20-9615' title='&lt;\/span&gt;&lt;a href=&quot;http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;dopt=Abstract&amp;amp;list_uids=34544853&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Dromerick AW, Geed S, Barth J, Brady K, Giannetti ML, Mitchell A, Edwardson MA, Tan MT, Zhou Y, Newport EL, Edwards DF. Estudo do Per&iacute;odo Cr&iacute;tico ap&oacute;s Acidente Vascular Cerebral (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2026676118. doi: 10.1073\/pnas.2026676118. PMID: 34544853; PMCID: PMC8488696.&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>20<\/sup><\/a><\/span>ou estabelecer a domin\u00e2ncia ocular<span id='easy-footnote-21-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-21-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/29905116\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Hensch TK, Quinlan EM. Per&iacute;odos cr&iacute;ticos na ambliopia. Vis Neurosci. 2018 Jan;35:E014. doi: 10.1017\/S0952523817000219. Errata em: Vis Neurosci. 2018 Jan;35:E024. PMID: 29905116; PMCID: PMC6047524.&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>21<\/sup><\/a><\/span>. \u00c9 nestes per\u00edodos cr\u00edticos, explica o Professor Associado de Neuroci\u00eancias da Johns Hopkins, Dr. G\u00fcl D\u00f6len, que o c\u00e9rebro est\u00e1 mais aberto a novas aprendizagens, uma recetividade que diminui com o tempo.<\/span><\/p>\n<div>&nbsp;<\/div>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h2>A neuroplasticidade cria uma \"janela de oportunidade\"<\/h2>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>\u00c0 semelhan\u00e7a do per\u00edodo cr\u00edtico, a neuroplasticidade desempenha um papel fundamental no rescaldo e na possibilidade de transforma\u00e7\u00e3o de uma experi\u00eancia psicad\u00e9lica. A neuroplasticidade refere-se \u00e0 capacidade do c\u00e9rebro para se reorganizar e alterar a sua estrutura f\u00edsica e organiza\u00e7\u00e3o funcional em resposta a exig\u00eancias ambientais, aprendizagem e experi\u00eancias. As crian\u00e7as t\u00eam n\u00edveis mais elevados de neuroplasticidade do que os adultos e, por conseguinte, uma melhor capacidade de aprendizagem e desenvolvimento. Descobriu-se que subst\u00e2ncias psicad\u00e9licas como o LSD e a psilocibina estimulam os processos de neuroplasticidade estrutural a n\u00edvel molecular e celular.<span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-22-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-22-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X15000097?via%3Dihub&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Bouso, J. C., Palhano-Fontes, F., Rodr&iacute;guez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E., De Araujo, D. B., &amp;amp; Riba, J. (2015). O uso prolongado de drogas psicad&eacute;licas est&aacute; associado a diferen&ccedil;as na estrutura cerebral e na personalidade em humanos. &lt;em&gt;Neuropsicofarmacologia Europeia&lt;\/em&gt;, &lt;em&gt;25&lt;\/em&gt;(4), 483-492. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.01.008&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); letter-spacing: 0px; text-align: var(--text-align);&quot;&gt;'><sup>22<\/sup><\/a><\/span><\/span> Estudos demonstram que uma \u00fanica dose destas subst\u00e2ncias pode estimular de forma aguda a neuroplasticidade, com efeitos a longo prazo ap\u00f3s uma \u00fanica dose.<span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-23-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-23-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X15000097?via%3Dihub&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Bouso, J. C., Palhano-Fontes, F., Rodr&iacute;guez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E., De Araujo, D. B., &amp;amp; Riba, J. (2015). O uso prolongado de drogas psicad&eacute;licas est&aacute; associado a diferen&ccedil;as na estrutura cerebral e na personalidade em humanos. &lt;em&gt;Neuropsicofarmacologia Europeia&lt;\/em&gt;, &lt;em&gt;25&lt;\/em&gt;(4), 483-492. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.01.008&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); letter-spacing: 0px; text-align: var(--text-align);&quot;&gt;'><sup>23<\/sup><\/a><\/span><\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>A neuroplasticidade e o per\u00edodo cr\u00edtico mostram que os psicad\u00e9licos criam \"uma janela de oportunidade\" para a transforma\u00e7\u00e3o. A investiga\u00e7\u00e3o tem demonstrado melhorias a longo prazo no bem-estar e na qualidade de vida ap\u00f3s o consumo de subst\u00e2ncias psicad\u00e9licas, especialmente em indiv\u00edduos saud\u00e1veis que s\u00e3o espiritualmente activos ou que enfrentam problemas de fim de vida.<span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-24-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-24-9615' title=' &lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/18593735\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Griffiths R, Richards W, Johnson M, McCann U, Jesse R. Experi&ecirc;ncias de tipo m&iacute;stico ocasionadas pela psilocibina medeiam a atribui&ccedil;&atilde;o de significado pessoal e espiritual 14 meses mais tarde. J Psychopharmacol Oxf Engl 2008; 22: 621-32&lt;\/a&gt;'><sup>24<\/sup><\/a><\/span><\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">&nbsp;<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">Estudos sobre a psilocibina e o LSD revelaram melhorias duradouras no bem-estar. Um estudo significativo realizado por Griffiths et al. (2006) revelou que, em indiv\u00edduos saud\u00e1veis, dois meses ap\u00f3s uma sess\u00e3o de psilocibina, 79% dos participantes relataram um aumento moderado (50%) a muito (29%) no seu bem-estar ou satisfa\u00e7\u00e3o com a vida. Para al\u00e9m disso, este efeito ben\u00e9fico parece perdurar, com 64% dos participantes a reportarem a mesma melhoria num seguimento de 14 meses.<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-25-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-25-9615' title=' &lt;a href=&quot;https:\/\/pubmed.ncbi.nlm.nih.gov\/18593735\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Griffiths R, Richards W, Johnson M, McCann U, Jesse R. Experi&ecirc;ncias de tipo m&iacute;stico ocasionadas pela psilocibina medeiam a atribui&ccedil;&atilde;o de significado pessoal e espiritual 14 meses mais tarde. J Psychopharmacol Oxf Engl 2008; 22: 621-32&lt;\/a&gt;'><sup>25<\/sup><\/a><\/span> <\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">&nbsp;Quando utilizada no contexto e ambiente correctos, com orienta\u00e7\u00e3o, e combinada com um trabalho de prepara\u00e7\u00e3o e integra\u00e7\u00e3o intencional, os benef\u00edcios de uma experi\u00eancia psicad\u00e9lica s\u00e3o suscept\u00edveis de persistir para al\u00e9m do per\u00edodo agudo de p\u00f3s-brilho.&nbsp;<\/span><\/p>\n<p><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h2>Uma compreens\u00e3o neurocient\u00edfica da experi\u00eancia psicad\u00e9lica<\/h2>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>V\u00e1rias culturas ao longo do tempo e do espa\u00e7o constru\u00edram a sua compreens\u00e3o da experi\u00eancia psicad\u00e9lica,&nbsp;<a href=\"https:\/\/evolute-institute.com\/pt\/historia_da_psicadelica\/\" target=\"_blank\" rel=\"noopener\">aprende sobre o uso antigo destas tecnologias da consci\u00eancia<\/a>. No Ocidente, em 2023, o modelo REBUS (<b>RE<\/b>relaxado <b>B<\/b>eliefs <b>U<\/b>nder p<b>S<\/b>A teoria do \"c\u00e9rebro an\u00e1rquico\" representa a teoria de ponta na compreens\u00e3o das experi\u00eancias psicad\u00e9licas.&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Proposto por Carhart-Harris e K. J. Friston, o modelo REBUS sugere que os psicad\u00e9licos actuam relaxando os pressupostos, cren\u00e7as ou \"antecedentes\" do c\u00e9rebro, que s\u00e3o as melhores suposi\u00e7\u00f5es ou previs\u00f5es do nosso c\u00e9rebro sobre o mundo com base em experi\u00eancias passadas. Por exemplo, a tua cren\u00e7a sobre como um estranho ir\u00e1 reagir se lhe fizeres um elogio depender\u00e1 muito da tua experi\u00eancia anterior, provavelmente na tua inf\u00e2ncia, quando te aproximaste de um estranho e como ele reagiu a ti. Este relaxamento das nossas cren\u00e7as (antecedentes) permite que a informa\u00e7\u00e3o sensorial de baixo para cima, muitas vezes suprimida por esses antecedentes, flua mais livremente e influencie a nossa consci\u00eancia.<\/p>\n<p>Al\u00e9m disso, o modelo REBUS postula que as condi\u00e7\u00f5es cerebrais induzidas pelas subst\u00e2ncias psicad\u00e9licas, tais como o aumento da entropia cerebral e o relaxamento dos antecedentes, criam um ambiente ideal para reformular cren\u00e7as de alto n\u00edvel. Este estado de esp\u00edrito mais flex\u00edvel e aberto \u00e9 adequado para fomentar a introspe\u00e7\u00e3o e a mudan\u00e7a de perspetiva. Este modelo de relaxamento e revis\u00e3o de cren\u00e7as, assistido farmacologicamente, pode desempenhar um papel fundamental no futuro dos cuidados de sa\u00fade mental, aumentando potencialmente a efic\u00e1cia dos tratamentos actuais.<\/p>\n<p>Por exemplo, em vez de seres influenciado principalmente pelas tuas cren\u00e7as (que se baseiam na tua experi\u00eancia anterior), podes mergulhar mais profundamente no momento presente e observar o que realmente \u00e9, em vez do que supuseste que seria. Voltando \u00e0 ideia de fazeres um elogio a um estranho, a experi\u00eancia do momento presente de <span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">Veres que o desconhecido aprecia o teu elogio e te devolve um,&nbsp;<\/span><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\">pode sobrepor-se \u00e0 tua cren\u00e7a de que as pessoas se v\u00e3o rir de ti ou repudiar sempre que te aproximas delas. Este processo de relaxamento de cren\u00e7as come\u00e7a com o efeito dos psicad\u00e9licos nos receptores 5-HT2AR e pode ser observado como um aumento da entropia ou desordem da atividade cerebral.<\/span><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Um vasto leque de experi\u00eancias psicad\u00e9licas, incluindo a emerg\u00eancia de material previamente inconsciente na consci\u00eancia, pode ser explicado atrav\u00e9s do modelo REBUS. Ao afrouxar o controlo dos antecedentes de alto n\u00edvel, que geralmente resumem e suprimem o conte\u00fado potencial das nossas mentes e do mundo exterior, os psicad\u00e9licos libertam esse conte\u00fado suprimido.&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Como j\u00e1 foi referido, foram propostas cr\u00edticas v\u00e1lidas ao modelo REBUS. Este debate \u00e9 de natureza metaf\u00edsica, uma vez que se confronta com o (in)famoso \"problema dif\u00edcil da consci\u00eancia\", que diz respeito \u00e0 quest\u00e3o de saber se a consci\u00eancia emerge do c\u00e9rebro ou se \u00e9 anterior a ele. Deixamos isso para a tua pr\u00f3pria explora\u00e7\u00e3o.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Uma destas cr\u00edticas vem do Dr. Bernardo Kastrup, que contrap\u00f5e o modelo REBUS atrav\u00e9s da sua teoria do idealismo anal\u00edtico. Um dos seus argumentos questiona a proposi\u00e7\u00e3o de entropia ou desordem no c\u00e9rebro psicad\u00e9lico devido \u00e0 natureza altamente ordenada da experi\u00eancia psicad\u00e9lica:&nbsp;&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<blockquote>\n<p><i><b>\"Como \u00e9 que \u00e9 poss\u00edvel que experi\u00eancias que as pessoas classificam entre as 5 mais significativas das suas vidas estejam associadas ao facto de o c\u00e9rebro adormecer?&nbsp;<\/b><\/i><br><i><b>- Bernardo Kastrup&nbsp;<\/b><\/i><span style=\"color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;\"><span id='easy-footnote-26-9615' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/evolute-institute.com\/pt\/psychedelics\/your-brain-on-psychedelics-psychedelic-neuroscience\/#easy-footnote-bottom-26-9615' title='&lt;\/span&gt;&lt;a href=&quot;https:\/\/www.youtube.com\/watch?v=B4RsXr02M0U&amp;amp;ab_channel=EssentiaFoundation&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Evid&ecirc;ncia emp&iacute;rica para o Idealismo Anal&iacute;tico (Parte 5) | Idealismo Anal&iacute;tico com Bernardo Kastrup&lt;\/a&gt;&lt;span style=&quot;color: var( --e-global-color-text ); text-align: var(--text-align); letter-spacing: 0px;&quot;&gt;'><sup>26<\/sup><\/a><\/span><\/span><\/p>\n<p><i><b>&nbsp;<\/b><\/i><\/p>\n<\/blockquote>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<h3>A neuroci\u00eancia, mas uma perspetiva da experi\u00eancia psicad\u00e9lica<\/h3>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>A neuroci\u00eancia dos psicad\u00e9licos, um campo em r\u00e1pida evolu\u00e7\u00e3o, continua a lan\u00e7ar luz sobre a nossa compreens\u00e3o destas tecnologias da consci\u00eancia.&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>T\u00e9cnicas como EEG, MEG e fMRI mostraram que, ao interagir com o sistema serotonin\u00e9rgico do nosso c\u00e9rebro, especificamente os receptores 5-HT2A, os psicad\u00e9licos como o LSD, a psilocibina e o DMT t\u00eam um impacto profundo na fun\u00e7\u00e3o e estrutura do c\u00e9rebro, atrav\u00e9s da neuroplasticidade e da reabertura de per\u00edodos cr\u00edticos. O aumento da flexibilidade mental, a resolu\u00e7\u00e3o criativa de problemas e a auto-perce\u00e7\u00e3o indicam o potencial para interven\u00e7\u00f5es terap\u00eauticas e crescimento pessoal.&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Embora tenham sido dados passos significativos, lembra-te que a nossa compreens\u00e3o ainda est\u00e1 a evoluir. Al\u00e9m disso, diferentes culturas ao longo do tempo constru\u00edram os seus entendimentos sobre o significado da experi\u00eancia psicad\u00e9lica. A integra\u00e7\u00e3o de teorias cognitivas e neurocient\u00edficas como o modelo REBUS s\u00e3o tentativas cont\u00ednuas de aprofundar a nossa compreens\u00e3o destes processos intrincados numa teoria abrangente. N\u00e3o podemos compreend\u00ea-los apenas a partir do exterior, a perspetiva fenomenol\u00f3gica\/da primeira pessoa tamb\u00e9m \u00e9 fundamental. Para come\u00e7ares a tua pr\u00f3pria explora\u00e7\u00e3o, recomendamos esta explora\u00e7\u00e3o do \"<a href=\"https:\/\/evolute-institute.com\/pt\/psicadelicos-e-realidade-mudar-o-paradigma-ocidental\/\" target=\"_blank\" rel=\"noopener\">mudan\u00e7a de paradigma<\/a>\"<\/p><p><br><\/p><p><span style=\"font-size: 19.2px;\">Tem em aten\u00e7\u00e3o que n\u00e3o fornecemos aconselhamento m\u00e9dico e que deves sempre procurar ajuda de um profissional de sa\u00fade antes de tomares qualquer decis\u00e3o sobre o consumo de subst\u00e2ncias psicad\u00e9licas.<\/span><br><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-024fb11 elementor-widget elementor-widget-text-editor\" data-id=\"024fb11\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6><b>Refer\u00eancias<\/b><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-923607d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"923607d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-176341c8 e-con-full e-flex e-con e-parent\" data-id=\"176341c8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-70b8f417 e-flex e-con-boxed e-con e-child\" data-id=\"70b8f417\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31cc24cb elementor-widget-tablet__width-inherit elementor-widget elementor-widget-image\" data-id=\"31cc24cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/evolute-institute.com\/wp-content\/uploads\/elementor\/thumbs\/Dimi_square_small-quwrl0uy8h45j3yjqp1hxd4h7qll64z8ll1tf84c0g.jpg\" title=\"Dimi_square_small\" alt=\"Dimi_square_small\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-349abf85 elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"349abf85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Dmitrij Achelrod<\/strong>,<\/p><p>Cofundador Evolute Institute<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22668724 e-con-full e-flex e-con e-child\" data-id=\"22668724\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f6c2512 elementor-widget elementor-widget-heading\" data-id=\"7f6c2512\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Sentes-te inspirado?<br>Vamos falar<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-122b1000 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"122b1000\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Convidamos-te a marcar uma chamada connosco. Juntos, podemos aprofundar todas as quest\u00f5es que possas ter. Podemos explorar se um dos nossos programas de retiro \u00e9 adequado para ti neste momento.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2dec6f54 elementor-widget elementor-widget-html\" data-id=\"2dec6f54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<!-- Calendly link widget begin -->\r\n<link href=\"https:\/\/assets.calendly.com\/assets\/external\/widget.css\" rel=\"stylesheet\">\r\n<script src=\"https:\/\/assets.calendly.com\/assets\/external\/widget.js\" type=\"text\/javascript\" async><\/script>\r\n<div align=\"center\">\r\n    <a class=\"sch_appt_cal\" href=\"\" onclick=\"Calendly.initPopupWidget({url: 'https:\/\/calendly.com\/evolute_institute_da\/30-min-exploration-evolute'});return false;\">COME\u00c7A A TUA VIAGEM<\/a>\r\n    <!-- Calendly link widget end -->\r\n<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b1a6079 elementor-widget elementor-widget-text-editor\" data-id=\"5b1a6079\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68d44cc6 e-flex e-con-boxed e-con e-parent\" data-id=\"68d44cc6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Mergulha nos fundamentos neurobiol\u00f3gicos de subst\u00e2ncias psicoactivas como a psilocibina e o LSD. O artigo explora a forma como uma perspetiva cient\u00edfica nos pode ajudar a compreender o modo como as subst\u00e2ncias psicad\u00e9licas actuam no c\u00e9rebro.<\/p>","protected":false},"author":1491,"featured_media":9616,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[56,57,51],"tags":[],"class_list":["post-9615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all","category-research","category-psychedelics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Your Brain on Psychedelics: Intro to the Neuroscience of Psilocybin &amp; Co. | Evolute Institute<\/title>\n<meta name=\"description\" content=\"If you&#039;ve ever had a psychedelic experience, it&#039;s likely that you&#039;ve wondered &quot;How is that even possible?&quot; In this article on the neuroscience of psychedelics, Evolute Institute authors Nino Galvez Leferink &amp; 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