What is Psilocybin?

Psilocybin is a naturally occurring psychedelic compound found in certain species of Psilocybe mushrooms and truffles, often referred to as “magic mushrooms.” For centuries, these have been used in traditional and indigenous settings for healing, insight, and spiritual connection.

When ingested, psilocybin is converted into psilocin, which interacts with serotonin receptors (especially the 5-HT2A receptor). This interaction temporarily alters brain connectivity, helping to reduce rigid thought patterns and open new ways of thinking and feeling.

Research shows psilocybin decreases activity in the brain’s Default Mode Network (DMN) – linked to self-referential thinking – while increasing communication between areas that rarely connect. This enhances neuroplasticity, allowing for emotional release, creative insights, and new perspectives.

The legal status of psilocybin varies by country. In most parts of the world, psilocybin mushrooms are regulated substances.

Legal status in the Netherlands:

In the Netherlands, psilocybin-containing truffles are legal. At Evolute Institute, our psilocybin retreat in the Netherlands operates fully within the legal framework. 
 

When used responsibly in a safe, supportive, and professional environment, legal psilocybin can have profound mental-health benefits. Studies and personal accounts consistently report reduced symptoms of depression, anxiety, and addiction, alongside increases in well-being, emotional balance, and self-compassion. Many participants describe the experience as one of the most meaningful and healing moments of their lives, helping them reconnect with themselves and others on a deeper level.

At Evolute Institute, we offer high-impact personal development psilocybin retreats rooted in deep inner work.

By increasing cognitive flexibility and emotional openness, psilocybin can help participants see familiar situations in new ways. With guided preparation and integration, these insights often lead to lasting self-understanding and behavioral change.

Studies from institutions such as Johns Hopkins University and Imperial College London  highlight psilocybin’s potential to help with depression, anxiety, PTSD, addiction, and end-of-life distress. When paired with skilled facilitation and integration, psilocybin therapy can provide relief where traditional treatments fall short.

Rather than numbing symptoms, psilocybin invites deeper emotional awareness. Participants may revisit emotions or memories with compassion and clarity. Supported by trained facilitators, this process helps release emotional blockages.

In the Netherlands, psilocybin truffles (the sclerotia of psilocybin fungi) are legal, while psilocybin mushrooms remain prohibited. This legal distinction enables retreats to operate safely and professionally.

Choose a retreat that prioritizes safety and professionalism. Key factors include:

• Comprehensive medical and psychological screening
• Trained facilitators and a low participant-to-facilitator ratio (ideally 2:1 or lower)
• On-site medical support
• Structured preparation and integration
• Transparency about potential risks and contraindications
• A supportive, like-minded group environment

The effectiveness of psilocybin depends greatly on “set and setting.” A clear intention, expert guidance, safe environment, and community support amplify the potential for insight. At Evolute retreats, facilitators ensure emotional safety and help participants integrate their experiences into daily life, turning profound experiences into sustainable change.